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SIR3 chromatin-silencing protein SIR3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851163, updated on 5-Sep-2021

Summary

Gene symbol
SIR3
Gene description
chromatin-silencing protein SIR3
Primary source
SGD:S000004434
Locus tag
YLR442C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CMT1; MAR2; STE8
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Genomic context

See SIR3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1019315..1022251, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sec39p Neighboring gene ribosomal 40S subunit protein S1A Neighboring gene Ecm7p Neighboring gene Gmc2p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleosomal histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chromatin-silencing protein SIR3
NP_013547.3
  • Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1019315..1022251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182330.3NP_013547.3  TPA: chromatin-silencing protein SIR3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013547.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06701
    Conserved Domains (2) summary
    COG1474
    Location:528962
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    cd04720
    Location:5189
    BAH_Orc1p_Yeast; BAH, or Bromo Adjacent Homology domain, as present in Orc1p, which again is part of the Saccharomyces cerevisiae Sir1-origin recognition complex, and as present in Sir3p. The Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a ...
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