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SEC39 Sec39p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851161, updated on 13-Apr-2024

Summary

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Gene symbol
SEC39
Gene description
Sec39p
Primary source
SGD:S000004432
Locus tag
YLR440C
See related
AllianceGenome:SGD:S000004432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DSL3
Summary
Predicted to enable SNARE binding activity. Involved in ER-dependent peroxisome organization and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum membrane and nuclear envelope. Part of Dsl1/NZR complex. Colocalizes with peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SEC39 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (1015568..1017697, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene U4/U6-U5 snRNP complex subunit LSM3 Neighboring gene mitochondrial 54S ribosomal protein YmL4 Neighboring gene ribosomal 40S subunit protein S1A Neighboring gene chromatin-silencing protein SIR3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein. Sasvari Z, et al. Virology, 2013 Dec. PMID 24210096
  2. Isolation of Saccharomyces cerevisiae RNase T1 hypersensitive (rns) mutants and genetic analysis of the RNS1/DSL1 gene. Ishikawa T, et al. J Gen Appl Microbiol, 2005 Apr. PMID 15942868
  3. Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis. Perry RJ, et al. Eukaryot Cell, 2009 Jun. PMID 19346454, Free PMC Article
  4. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Tripathi A, et al. Nat Struct Mol Biol, 2009 Feb. PMID 19151722, Free PMC Article
  5. A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Ren Y, et al. Cell, 2009 Dec 11. PMID 20005805, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overall, Sec39p is the first peroxisomal biogenesis protein characterized that is critical for tombusvirus replication in yeast and plants.
    Title: Tombusvirus replication depends on Sec39p endoplasmic reticulum-associated transport protein.
  2. SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly.
    Title: Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
  3. Dsl3p (Sec39p) is required for the stable interaction of the SNARE Use1p with a central subcomplex consisting of Tip20p and the SNARE proteins Ufe1p and Sec20p. [DSL3]
    Title: Dsl1p, Tip20p, and the novel Dsl3(Sec39) protein are required for the stability of the Q/t-SNARE complex at the endoplasmic reticulum in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ER-dependent peroxisome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Dsl1/NZR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Dsl1/NZR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope HDA PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sec39p
NP_013545.3
  • Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    1015568..1017697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182328.3 → NP_013545.3  TPA: Sec39p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013545.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ75, Q12745, Q7LHI0
    UniProtKB/TrEMBL
    A0A8H4FBT6, G2WJQ1, N1P097
    Conserved Domains (1) summary
    pfam08314
    Location:7 → 688
    Sec39; Secretory pathway protein Sec39
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12745.1

Gene LinkOut

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