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SEN1 DNA/RNA helicase SEN1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851150, updated on 17-May-2024

Summary

Gene symbol
SEN1
Gene description
DNA/RNA helicase SEN1
Primary source
FungiDB:YLR430W
Locus tag
YLR430W
See related
SGD:S000004422; AllianceGenome:SGD:S000004422; VEuPathDB:YLR430W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CIK3; NRD2
Summary
Enables 5'-3' DNA helicase activity; 5'-3' DNA/RNA helicase activity; and protein domain specific binding activity. Involved in cell redox homeostasis; nucleic acid metabolic process; and regulation of transcription from RNA polymerase II promoter in response to DNA damage. Located in cytoplasm; nucleus; and replication fork. Part of Nrd1 complex. Used to study amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2. Orthologous to human SETX (senataxin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SEN1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (993434..1000129)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Mag2p Neighboring gene Crn1p Neighboring gene Atg23p Neighboring gene IMP dehydrogenase IMD3

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5'-3' DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-3' DNA/RNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding HDA PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein domain specific binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription termination site sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA-templated DNA replication maintenance of fidelity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA-templated transcription termination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in snRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sno(s)RNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in termination of RNA polymerase II transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in termination of RNA polymerase II transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in termination of RNA polymerase III transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription-coupled nucleotide-excision repair IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Nrd1 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA/RNA helicase SEN1
NP_013534.3
  • ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    993434..1000129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182318.3NP_013534.3  TPA: DNA/RNA helicase SEN1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013534.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ65, E9P9Z4, Q00416, Q06448
    UniProtKB/TrEMBL
    A0A8H4BXU8, B3RHT9, N1P7F6
    Conserved Domains (2) summary
    COG1112
    Location:10061858
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam12726
    Location:106859
    SEN1_N; SEN1 N terminal