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TDA5 Tda5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851146, updated on 23-Apr-2026
Official Symbol
TDA5
Official Full Name
Tda5p
Primary source
SGD:S000004418
Locus tag
YLR426W
See related
AllianceGenome:SGD:S000004418; FungiDB:YLR426W; VEuPathDB:YLR426W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in response to xenobiotic stimulus. Located in endoplasmic reticulum and mitochondrion. Orthologous to several human genes including DHRS3 (dehydrogenase/reductase 3); HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11); and HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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Location:
chromosome: XII
Exon count:
2
Sequence:
Chromosome: XII; NC_001144.5 (987062..988113)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene Rho family guanine nucleotide exchange factor TUS1 Neighboring gene RING-type E3 ubiquitin transferase MAG2 Neighboring gene coronin

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Use of a genome-wide approach to identify new genes that control resistance of Saccharomyces cerevisiae to ionizing radiation. Game JC, et al. Radiat Res, 2003 Jul. PMID 12816519
  2. Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop. Vazquez HM, et al. PLoS Genet, 2016 Jul. PMID 27462707, Free PMC Article
  3. Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. Lee W, et al. PLoS Genet, 2005 Aug. PMID 16121259, Free PMC Article
  4. Identification and characterization of Prp45p and Prp46p, essential pre-mRNA splicing factors. Albers M, et al. RNA, 2003 Jan. PMID 12554883, Free PMC Article
  5. A Genetic Screen To Identify Genes Influencing the Secondary Redox Couple NADPH/NADP(+) in the Yeast Saccharomyces cerevisiae. Yadav S, et al. G3 (Bethesda), 2020 Jan 7. PMID 31757928, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to xenobiotic stimulus HMP PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
Preferred Names
Tda5p
NP_013530.1
  • hypothetical protein; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    987062..988113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182314.1 → NP_013530.1  Tda5p

    See identical proteins and their annotated locations for NP_013530.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ62, Q06417
    UniProtKB/TrEMBL
    A7A1U7, B3RHT6, C8ZE34, G2WJN8, N1P1X5
    Conserved Domains (1) summary
    cl21454
    Location:72 → 309
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06417.1

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