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VPS36 ESCRT-II subunit protein VPS36 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851135, updated on 4-Aug-2021

Summary

Gene symbol
VPS36
Gene description
ESCRT-II subunit protein VPS36
Primary source
SGD:S000004409
Locus tag
YLR417W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GRD12; VAC3; VPL11
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Genomic context

See VPS36 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (955010..956710)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pun1p Neighboring gene uncharacterized protein Neighboring gene Cdc73p Neighboring gene putative helicase

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the VPS36 gene: The VPS36 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ESCRT II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESCRT II complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ESCRT II complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ESCRT-II subunit protein VPS36
NP_013521.3
  • Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome; plays a role in the formation of mutant huntingtin (Htt) aggregates in yeast

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    955010..956710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182305.3NP_013521.3  TPA: ESCRT-II subunit protein VPS36 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013521.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q06696
    Conserved Domains (5) summary
    smart00547
    Location:179203
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:118146
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd13227
    Location:4122
    PH-GRAM-like_Vps36; Pleckstrin homology-like domain or GLUE (GRAM-like ubiquitin-binding in Eap45) domain of Vps36
    pfam04157
    Location:323549
    EAP30; EAP30/Vps36 family
    pfam16988
    Location:109164
    Vps36-NZF-N; Vacuolar protein sorting 36 NZF-N zinc-finger domain
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