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UTP21 rRNA-processing protein UTP21 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851125, updated on 13-Apr-2024

Summary

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Gene symbol
UTP21
Gene description
rRNA-processing protein UTP21
Primary source
SGD:S000004401
Locus tag
YLR409C
See related
AllianceGenome:SGD:S000004401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in rRNA processing. Located in nucleolus. Part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Human ortholog(s) of this gene implicated in glaucoma and primary open angle glaucoma. Orthologous to human WDR36 (WD repeat domain 36). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (934414..937233, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Gag1p Neighboring gene Bls1p Neighboring gene inositol polyphosphate kinase VIP1 Neighboring gene gag protein Neighboring gene gag-pol fusion protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis. Zhang C, et al. PLoS One, 2014. PMID 24466140, Free PMC Article
  2. Glaucoma-associated WDR36 variants encode functional defects in a yeast model system. Footz TK, et al. Hum Mol Genet, 2009 Apr 1. PMID 19150991
  3. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits. Zhang C, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27330138, Free PMC Article
  4. 90S pre-ribosome transformation into the primordial 40S subunit. Cheng J, et al. Science, 2020 Sep 18. PMID 32943521
  5. A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Champion EA, et al. Mol Cell Biol, 2008 Nov. PMID 18725399, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Residues 100-190 of Utp18 bind to the tandem WD domain of Utp21.
    Title: Structure of Utp21 tandem WD domain provides insight into the organization of the UTPB complex involved in ribosome synthesis.
  2. The interaction between the half-a-tetratricopeptide repeat (HAT) domain of Utp6 and a specific peptide in Utp21, is investigated.
    Title: A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of Pwp2p-containing subcomplex of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Pwp2p-containing subcomplex of 90S preribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rRNA-processing protein UTP21
NP_013513.3
  • Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    934414..937233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182297.3 → NP_013513.3  TPA: rRNA-processing protein UTP21 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013513.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ43, Q06078
    UniProtKB/TrEMBL
    A0A8H4FA38, N1NYT4
    Conserved Domains (4) summary
    cd00200
    Location:284 → 613
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:464 → 500
    7WD40; WD40 repeat [structural motif]
    pfam04192
    Location:695 → 937
    Utp21; Utp21 specific WD40 associated putative domain
    cl29593
    Location:81 → 377
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
5JPQ_I.1
6KE6_BE.1
6LQP_BE.1
6LQQ_BE.1
6LQR_BE.1
6LQS_BE.1
6LQT_BE.1
6LQU_BE.1
6LQV_BE.1
6ZQA_u.1
6ZQB_u.1
6ZQC_u.1
6ZQD_u.1
6ZQE_u.1
6ZQF_u.1
7AJT_u.1
7AJU_u.1
Q06078.1

Gene LinkOut

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