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SEI1 seipin [ Saccharomyces cerevisiae S288C ]

Gene ID: 851120, updated on 3-Jun-2026
Official Symbol
SEI1
Official Full Name
seipin
Primary source
SGD:S000004396
Locus tag
YLR404W
See related
AllianceGenome:SGD:S000004396; FungiDB:YLR404W; VEuPathDB:YLR404W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FLD1
Summary
Involved in lipid droplet formation; protein localization; and regulation of lipid biosynthetic process. Acts upstream of or within acylglycerol homeostasis and phospholipid homeostasis. Located in cortical endoplasmic reticulum and endoplasmic reticulum membrane. Used to study congenital generalized lipodystrophy and congenital generalized lipodystrophy type 2. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See SEI1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (928743..929600)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA dihydrouridine synthase DUS3 Neighboring gene zinc-coordinating transcription factor SFP1 Neighboring gene tRNA dihydrouridine synthase Neighboring gene 60S ribosomal protein eL31 RPL31B

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The luminal domain region of Seipin/Fld1 is dispensable for establishing functional ER sites for lipid droplet biogenesis. Khatri A, et al. Nat Commun, 2025 Nov 27. PMID 41309574, Free PMC Article
  2. Seipin is a discrete homooligomer. Binns D, et al. Biochemistry, 2010 Dec 21. PMID 21062080, Free PMC Article
  3. A role for seipin in lipid droplet dynamics and inheritance in yeast. Wolinski H, et al. J Cell Sci, 2011 Nov 15. PMID 22100922
  4. Seipin governs phosphatidic acid homeostasis at the inner nuclear membrane. Romanauska A, et al. Nat Commun, 2024 Dec 2. PMID 39622802, Free PMC Article
  5. Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. Fei W, et al. J Cell Biol, 2008 Feb 11. PMID 18250201, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters.
    Title: Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters.
  2. Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis.
    Title: Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis.
  3. The negative regulation of sphingolipid synthesis by Saccharomyces cerevisiae seipin is likely an evolutionarily conserved process.
    Title: Seipin negatively regulates sphingolipid production at the ER-LD contact site.
  4. Proper droplet formation requires the collaboration of Sei1p and Ldb16.
    Title: Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p.
  5. The Fld1/Ldb16 complex facilitates the establishment of lipid droplet (LD) identity by acting as a diffusion barrier at the endoplasmic reticulum-LD contact sites.
    Title: The seipin complex Fld1/Ldb16 stabilizes ER-lipid droplet contact sites.
  6. Seipin has dissectible roles in both promoting early lipid droplet (LD) initiation and in regulating LD morphology.
    Title: Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.
  7. Fld1(seipin)-Ldb16 complex affects phosphatidic acid homeostasis at an lipid droplets-forming subdomain of the nuclear envelope.
    Title: Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast.
  8. The stability of Ldb16 requires Fld1, as Ldb16 is subjected to ER-associated degradation (ERAD) in the absence of Fld1 but is stabilized when Fld1 is present.
    Title: Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16.
  9. Deletion of FLD1, encoding seipin, leads to impaired dynamics of lipid droplets and defective lipolysis.
    Title: A role for seipin in lipid droplet dynamics and inheritance in yeast.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acylglycerol homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to lipid droplet IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
seipin
NP_013508.3
  • Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation; ensures LDs bud from the ER towards the cytosolic side of the membrane; subunit of the lipid droplet assembly complex; stabilizes ER-LD contact sites in complex with Ldb16p; regulates PA and DAG homeostasis at the inner nuclear membrane preserving envelope integrity; human homolog BSCL2 implicated in congenital lipodystrophy, complements yeast null mutant

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    928743..929600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182292.3 → NP_013508.3  seipin

    See identical proteins and their annotated locations for NP_013508.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZ37, Q06058
    UniProtKB/TrEMBL
    A0ABF7PIU4, A7A1S7, B3RHR6, C7GXK6, C8ZE13, G2WJL7, N1NYT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06058.1

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