U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IKI3 Elongator subunit IKI3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851100, updated on 18-Jan-2023

Summary

Gene symbol
IKI3
Gene description
Elongator subunit IKI3
Primary source
SGD:S000004376
Locus tag
YLR384C
See related
AllianceGenome:SGD:S000004376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ELP1; KTI7; TOT1
Summary
Enables tRNA binding activity. Involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Located in cytoplasm and nucleus. Part of elongator holoenzyme complex. Used to study Riley-Day syndrome. Human ortholog(s) of this gene implicated in Riley-Day syndrome; asthma; medulloblastoma; and scoliosis. Orthologous to human ELP1 (elongator acetyltransferase complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See IKI3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (888851..892900, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene leucine--tRNA ligase NAM2 Neighboring gene DNA repair protein SMC6 Neighboring gene Swc7p Neighboring gene Vac14p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the IKI3 gene: The IKI3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble uridine modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Elongator subunit IKI3
NP_013488.3
  • Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    888851..892900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182273.3NP_013488.3  TPA: Elongator subunit IKI3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013488.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O00036, Q06706
    UniProtKB/TrEMBL
    A0A8H4BZT0
    Conserved Domains (2) summary
    COG5290
    Location:181348
    COG5290; IkappaB kinase complex, IKAP component [Transcription]
    sd00006
    Location:10041034
    TPR; TPR repeat [structural motif]