Format

Send to:

Choose Destination

NAM2 leucine--tRNA ligase NAM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851098, updated on 9-Sep-2018

Summary

Gene symbol
NAM2
Gene description
leucine--tRNA ligase NAM2
Primary source
SGD:S000004374
Locus tag
YLR382C
Gene type
protein coding
RNA name
leucine--tRNA ligase NAM2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MSL1

Genomic context

See NAM2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (882067..884751, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Csr1p Neighboring gene Ctf3p Neighboring gene DNA repair protein SMC6 Neighboring gene Elongator subunit IKI3

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the NAM2 gene: The NAM2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
leucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leucine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
leucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
mRNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Group I intron splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
 
leucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leucyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
leucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translation IGI
Inferred from Genetic Interaction
more info
PubMed 
tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine--tRNA ligase NAM2
NP_013486.3
  • Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    882067..884751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182271.3NP_013486.3  TPA: leucine--tRNA ligase NAM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013486.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11325
    Conserved Domains (4) summary
    cd00812
    Location:49685
    LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
    TIGR00396
    Location:21893
    leuS_bact; leucyl-tRNA synthetase, eubacterial and mitochondrial family
    pfam13603
    Location:236447
    tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    cl12020
    Location:685803
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains
Support Center