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ROM2 Rho family guanine nucleotide exchange factor ROM2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851086, updated on 12-Aug-2018

Summary

Gene symbol
ROM2
Gene description
Rho family guanine nucleotide exchange factor ROM2
Primary source
SGD:S000004363
Locus tag
YLR371W
Gene type
protein coding
RNA name
Rho family guanine nucleotide exchange factor ROM2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See ROM2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (862714..866784)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Hsp70 family ATPase SSQ1 Neighboring gene Arc18p Neighboring gene fatty acid elongase ELO3 Neighboring gene Vid22p

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Rho guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
PubMed 
guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell periphery HDA PubMed 
cellular bud tip IDA
Inferred from Direct Assay
more info
PubMed 
incipient cellular bud site IDA
Inferred from Direct Assay
more info
PubMed 
mating projection tip IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
Rho family guanine nucleotide exchange factor ROM2
NP_013475.1
  • Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    862714..866784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182260.1NP_013475.1  TPA: Rho family guanine nucleotide exchange factor ROM2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P51862
    Conserved Domains (5) summary
    smart00036
    Location:10331342
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    COG5422
    Location:41356
    ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    cd04435
    Location:420501
    DEP_fRom2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) Rom2-like proteins. Rom2-like proteins share a common domain architecture, containing, beside the RhoGEF domain, a DEP, a PH (pleckstrin homology) and a CNH ...
    pfam00621
    Location:663845
    RhoGEF; RhoGEF domain
    pfam15405
    Location:8811011
    PH_5; Pleckstrin homology domain
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