ILV5 ketol-acid reductoisomerase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ILV5
Official Full Name: ketol-acid reductoisomerase
Primary source: SGD:S000004347
Locus tag: YLR355C
See related: AllianceGenome:SGD:S000004347; FungiDB:YLR355C; VEuPathDB:YLR355C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables double-stranded DNA binding activity and ketol-acid reductoisomerase activity. Involved in branched-chain amino acid biosynthetic process and mitochondrial genome maintenance. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

direct binding of Ilv5p can aid in the maintenance and stabilization of mtDNA
Title: Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables ketol-acid reductoisomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketol-acid reductoisomerase activity	IEA Inferred from Electronic Annotation more info
enables ketol-acid reductoisomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ketol-acid reductoisomerase activity	RCA inferred from Reviewed Computational Analysis more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-isoleucine biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-valine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-valine biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in branched-chain amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in branched-chain amino acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branched-chain amino acid biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in negative regulation of mitochondrial DNA metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitochondrial DNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_013459.1

Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids