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NUP2 nucleoporin NUP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 851048, updated on 15-Mar-2026
Official Symbol
NUP2
Official Full Name
nucleoporin NUP2
Primary source
SGD:S000004327
Locus tag
YLR335W
See related
AllianceGenome:SGD:S000004327; FungiDB:YLR335W; VEuPathDB:YLR335W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small GTPase binding activity. A structural constituent of nuclear pore. Involved in several processes, including constitutive heterochromatin formation; nucleocytoplasmic transport; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in mitochondrion. Part of nuclear pore cytoplasmic filaments and nuclear pore nuclear basket. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to human RANBP2 (RAN binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See NUP2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (797430..799592)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein eS25 RPS25B Neighboring gene tRNA-Glu Neighboring gene Sgd1p Neighboring gene Vrp1p

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Transcriptional profiling on all open reading frames of Saccharomyces cerevisiae. Hauser NC, et al. Yeast, 1998 Sep 30. PMID 9791892
  2. Chromatin boundaries in budding yeast: the nuclear pore connection. Ishii K, et al. Cell, 2002 May 31. PMID 12062099
  3. Nuclear basket proteins Nup2 and Mlp1 drive heat shock-induced 3D genome restructuring downstream of transcriptional activation. Mohajan S, et al. J Biol Chem, 2025 Sep. PMID 40780415, Free PMC Article
  4. Structural basis for Nup2p function in cargo release and karyopherin recycling in nuclear import. Matsuura Y, et al. EMBO J, 2003 Oct 15. PMID 14532109, Free PMC Article
  5. Nup-PI: the nucleopore-promoter interaction of genes in yeast. Schmid M, et al. Mol Cell, 2006 Feb 3. PMID 16455493

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization.
    Title: Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization.
  2. The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae.
    Title: The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae.
  3. Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis.
    Title: Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis.
  4. While Nup60 is the unique target of genotoxic stress within the nuclear basket that probably belongs to the SUMO-mediated DNA damage response pathway, both Nup2 and Nup60 show a dramatic increase in SUMOylation upon osmotic stress, with Nup2 SUMOylation being enhanced in Nup60 SUMO-deficient mutant yeast strains.
    Title: SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses.
  5. Deleting NUP2 affects meiotic progression and spore viability. 125 aa region of Nup2 is necessary and sufficient for its meiotic function.
    Title: The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis.
  6. Nup2p and the Ran guanylyl-nucleotide exchange factor, Prp20p, interact at specific chromatin regions and enable the NPC to play an active role in chromatin organization by facilitating the transition of chromatin between activity states.
    Title: The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables importin-alpha family protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NLS-bearing protein import into nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus in response to heat stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein export from nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein localization to nuclear inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in silent mating-type cassette heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nuclear envelope NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore cytoplasmic filaments IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
nucleoporin NUP2
NP_013439.1
  • Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization; involved with Nup60p in nuclear basket remodeling during meiosis; Cdc5p-mediated phosphorylation of Nup60p leads to detachment and reattachment of nuclear basket

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    797430..799592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182224.1 → NP_013439.1  nucleoporin NUP2

    See identical proteins and their annotated locations for NP_013439.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYX5, P32499, Q06130
    UniProtKB/TrEMBL
    B3RHK8, B5VNM6, C7GUM1, G2WJF4, N1P016
    Conserved Domains (3) summary
    smart00160
    Location:588 → 715
    RanBD; Ran-binding domain
    PRK08581
    Location:233 → 486
    PRK08581; amidase domain-containing protein
    pfam08911
    Location:3 → 70
    NUP50; NUP50 (Nucleoporin 50 kDa)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32499.2

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