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SFH1 Sfh1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 851032, updated on 13-Apr-2024

Summary

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Gene symbol
SFH1
Gene description
Sfh1p
Primary source
SGD:S000004313
Locus tag
YLR321C
See related
AllianceGenome:SGD:S000004313
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable transcription coregulator activity. Involved in several processes, including chromatin remodeling; nucleic acid metabolic process; and regulation of nuclear cell cycle DNA replication. Part of RSC-type complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; atypical teratoid rhabdoid tumor; neurilemmomatosis; and rhabdoid cancer. Orthologous to human SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (776584..777864, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Bud6p Neighboring gene Mms22p Neighboring gene U2-type spliceosomal complex subunit CWC24 Neighboring gene peroxisome biogenesis protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes. Tripathi A, et al. Biochem Soc Trans, 2014 Oct. PMID 25233419, Free PMC Article
  2. Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution. Schaaf G, et al. Mol Biol Cell, 2011 Mar 15. PMID 21248202, Free PMC Article
  3. Complementation analyses suggest species-specific functions of the SNF5 homology domain. Bonazzi V, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16154112
  4. Abundance of the RSC nucleosome-remodeling complex is important for the cells to tolerate DNA damage in Saccharomyces cerevisiae. Koyama H, et al. FEBS Lett, 2002 Nov 6. PMID 12417315
  5. Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression. Cao Y, et al. Mol Cell Biol, 1997 Jun. PMID 9154831, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a model that Sfh1 promotes phosphatidylethanolamine production by Psd2 by transferring phospholipids between the ER and endosome.
    Title: Suppression of respiratory growth defect of mitochondrial phosphatidylserine decarboxylase deficient mutant by overproduction of Sfh1, a Sec14 homolog, in yeast.
  2. Data suggest that SFH1 and SEC14L undergo conformational changes as phosphatidylinositol/phosphatidylcholine bind to hydrophobic pockets/ligand binding sites. [review-like article]
    Title: Sec14-like phosphatidylinositol-transfer proteins and diversification of phosphoinositide signalling outcomes.
  3. Results identify mutations that confer Sec14-like activities to a functionally inert pseudo-Sec14 (Sfh1), which seemingly conserves all of the structural requirements for Sec14 function.
    Title: Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling at centromere IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of nuclear cell cycle DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RSC-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RSC-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF superfamily-type complex IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sfh1p
NP_013425.1
  • Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; hSNF5 tumor suppressor ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    776584..777864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182210.1 → NP_013425.1  TPA: Sfh1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013425.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYW4, Q06168
    UniProtKB/TrEMBL
    A0A6A5PTM8, A7A1K5, B3RHJ7, B5VNL7, C7GUB2, G2WJE3, N1NZM1
    Conserved Domains (1) summary
    pfam04855
    Location:204 → 391
    SNF5; SNF5 / SMARCB1 / INI1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6K15_G.1
6KW3_G.1
6KW4_G.1
6KW5_G.1
6TDA_K.1
6V8O_Q.1
6V92_Q.1
Q06168.1

Gene LinkOut

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