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MMP23B matrix metallopeptidase 23B [ Homo sapiens (human) ]

Gene ID: 8510, updated on 13-Mar-2020

Summary

Official Symbol
MMP23Bprovided by HGNC
Official Full Name
matrix metallopeptidase 23Bprovided by HGNC
Primary source
HGNC:HGNC:7171
See related
Ensembl:ENSG00000189409 MIM:603321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIFR; MMP22; MIFR-1; MMP23A
Summary
This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 4.1), prostate (RPKM 3.5) and 21 other tissues See more
Orthologs

Genomic context

See MMP23B in Genome Data Viewer
Location:
1p36.33
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1631681..1635638)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1567060..1570030)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378586 Neighboring gene fibronectin type III domain containing 10 Neighboring gene mindbomb E3 ubiquitin protein ligase 2 Neighboring gene cyclin dependent kinase 11B Neighboring gene solute carrier family 35 member E2B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene matrix metallopeptidase 23A (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metalloendopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
metallopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
reproduction IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
matrix metalloproteinase-23
Names
MMP-21
MMP-22
MMP-23
femalysin
matrix metalloproteinase 22
matrix metalloproteinase 23B
matrix metalloproteinase in the female reproductive tract
matrix metalloproteinase-21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006983.2NP_008914.1  matrix metalloproteinase-23 precursor

    See identical proteins and their annotated locations for NP_008914.1

    Status: REVIEWED

    Source sequence(s)
    AJ005256, FO704657
    Consensus CDS
    CCDS30559.1
    UniProtKB/Swiss-Prot
    O75900
    Related
    ENSP00000348308.5, ENST00000356026.10
    Conserved Domains (3) summary
    smart00408
    Location:313373
    IGc2; Immunoglobulin C-2 Type
    smart00254
    Location:255289
    ShKT; ShK toxin domain
    cd04278
    Location:87254
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1631681..1635638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002615.1XP_016858104.1  matrix metalloproteinase-23 isoform X1

  2. XM_017002617.1XP_016858106.1  matrix metalloproteinase-23 isoform X2

RNA

  1. XR_002957848.1 RNA Sequence

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