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SEC72 Sec63 complex subunit SEC72 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850999, updated on 5-Jul-2025
Official Symbol
SEC72
Official Full Name
Sec63 complex subunit SEC72
Primary source
SGD:S000004283
Locus tag
YLR292C
See related
AllianceGenome:SGD:S000004283; FungiDB:YLR292C; VEuPathDB:YLR292C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SEC67; SIM2
Summary
Enables protein transmembrane transporter activity. Involved in post-translational protein targeting to membrane, translocation. Located in endoplasmic reticulum. Part of Sec62/Sec63 complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SEC72 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (719789..720370, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ubiquinone biosynthesis protein COQ11 Neighboring gene translation initiation factor eIF2B subunit beta Neighboring gene Ran GTPase GSP1 Neighboring gene F1F0 ATP synthase subunit h

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Sec72p contributes to the selective recognition of signal peptides by the secretory polypeptide translocation complex. Feldheim D, et al. J Cell Biol, 1994 Aug. PMID 8051213, Free PMC Article
  2. Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae. Fang H, et al. Mol Biol Cell, 1994 Sep. PMID 7841522, Free PMC Article
  3. Novel β-structure of YLR301w from Saccharomyces cerevisiae. Kim KH, et al. Acta Crystallogr D Biol Crystallogr, 2012 May. PMID 22525751
  4. The tetratricopeptide repeats of receptors involved in protein translocation across membranes. Schlegel T, et al. Mol Biol Evol, 2007 Dec. PMID 17905998
  5. Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins. Tripathi A, et al. J Biol Chem, 2017 May 12. PMID 28286332, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-translational protein targeting to membrane, translocation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Sec62/Sec63 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
Preferred Names
Sec63 complex subunit SEC72
NP_013395.1
  • Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec66p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    719789..720370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182180.1 → NP_013395.1  TPA: Sec63 complex subunit SEC72

    See identical proteins and their annotated locations for NP_013395.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYT8, P39742
    UniProtKB/TrEMBL
    A7A1H5, B3RHH2, B5VNJ8, C7GVU5, C8ZDQ6, G2WJB6, N1P1I4
    Conserved Domains (2) summary
    PLN03088
    Location:143 → 189
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:139 → 169
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39742.3

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