ECI1 dodecenoyl-CoA isomerase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ECI1
Official Full Name: dodecenoyl-CoA isomerase
Primary source: SGD:S000004274
Locus tag: YLR284C
See related: AllianceGenome:SGD:S000004274; FungiDB:YLR284C; VEuPathDB:YLR284C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Orthologous to several human genes including CDYL2 (chromodomain Y like 2). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs: all
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Genomic context

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See ECI1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (706198..707040, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here the mode of binding of acyl-CoA substrate analogues to peroxisomal Dodecenoyl-CoA Isomerase Saccharomyces cerevisiae is described.
Title: Structures of yeast peroxisomal Δ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IEA Inferred from Electronic Annotation more info
enables delta(3)-delta(2)-enoyl-CoA isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dodecenoyl-CoA isomerase

NP_013386.1

EC 5.3.3.8

Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

706198..707040 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182171.1 → NP_013386.1 TPA: dodecenoyl-CoA isomerase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013386.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYS8, Q05871

UniProtKB/TrEMBL

A7A1G5, B3RHG3, B5VNJ0, C7GVS9, C8ZDP7, G2WJA6, N1NZJ5

Conserved Domains (1) summary

COG1024
Location:6 → 243

CaiD; Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]