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SEC22 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850973, updated on 22-Aug-2024

Summary

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Official Symbol
SEC22
Primary source
FungiDB:YLR268W
Locus tag
YLR268W
See related
SGD:S000004258; AllianceGenome:SGD:S000004258; VEuPathDB:YLR268W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLY2; TS26; TSL26
Summary
Enables SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vesicle fusion with Golgi apparatus. Located in ER to Golgi transport vesicle membrane; Golgi apparatus; and endoplasmic reticulum. Is integral component of membrane. Part of SNARE complex. Orthologous to several human genes including SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (680200..680844)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pdr8p Neighboring gene Bop2p Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase Neighboring gene Cmg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Derf A, et al. Bioorg Med Chem Lett, 2019 Feb 1. PMID 30579794
  2. Isolation, DNA sequence and regulation of a new cell division cycle gene from the yeast Saccharomyces cerevisiae. Hasegawa H, et al. Yeast, 1989 Nov-Dec. PMID 2694679
  3. Structural insight into the membrane insertion of tail-anchored proteins by Get3. Yamagata A, et al. Genes Cells, 2010 Jan. PMID 20015340
  4. Analysis of Sec22p in endoplasmic reticulum/Golgi transport reveals cellular redundancy in SNARE protein function. Liu Y, et al. Mol Biol Cell, 2002 Sep. PMID 12221135, Free PMC Article
  5. Yeast ER-Golgi v-SNAREs Bos1p and Bet1p differ in steady-state localization and targeting. Ossipov D, et al. J Cell Sci, 1999 Nov. PMID 10547372

See all (173) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNAP receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion with Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ER to Golgi transport vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex IEA
Inferred from Electronic Annotation
more info
  
located_in bounding membrane of organelle IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SNAP receptor SEC22
NP_013370.1
  • R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    680200..680844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182155.1 → NP_013370.1  TPA: SNAP receptor SEC22 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYR6, P22214
    UniProtKB/TrEMBL
    A7A1F0, B3RHF2, B5VNI0, C7GQX2, C8ZDN3, G2WJ94, N1NYH7
    Conserved Domains (1) summary
    COG5143
    Location:2 → 192
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22214.1

Gene LinkOut

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