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SEC22 SNAP receptor SEC22 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850973, updated on 18-Jan-2023

Summary

Gene symbol
SEC22
Gene description
SNAP receptor SEC22
Primary source
SGD:S000004258
Locus tag
YLR268W
See related
AllianceGenome:SGD:S000004258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLY2; TS26; TSL26
Summary
Enables SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; and vesicle fusion with Golgi apparatus. Located in ER to Golgi transport vesicle membrane; Golgi apparatus; and endoplasmic reticulum. Is integral component of membrane. Part of SNARE complex. Orthologous to several human genes including SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SEC22 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (680200..680844)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pdr8p Neighboring gene Bop2p Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase Neighboring gene Cmg1p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SEC22 gene: The SEC22 gene is conserved in human, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNAP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables SNAP receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ER to Golgi transport vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SNARE complex IEA
Inferred from Electronic Annotation
more info
 
located_in bounding membrane of organelle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SNAP receptor SEC22
NP_013370.1
  • R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    680200..680844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182155.1NP_013370.1  TPA: SNAP receptor SEC22 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYR6, P22214
    UniProtKB/TrEMBL
    A0A0L8VLE9, A0A6A5PSY8, A0A6C1DVY2, A7A1F0, B3RHF2, B5VNI0, C7GQX2, G2WJ94, H0GKI4, N1NYH7
    Conserved Domains (1) summary
    COG5143
    Location:2192
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]