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GSY2 glycogen (starch) synthase GSY2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850962, updated on 12-Apr-2026
Official Symbol
GSY2
Official Full Name
glycogen (starch) synthase GSY2
Primary source
SGD:S000004248
Locus tag
YLR258W
See related
AllianceGenome:SGD:S000004248; FungiDB:YLR258W; VEuPathDB:YLR258W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity and glycogen binding activity. Involved in glycogen biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in cardiovascular system disease and glycogen storage disease. Orthologous to human GYS1 (glycogen synthase 1) and GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See GSY2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (660716..662833)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene uncharacterized protein Neighboring gene chaperone ATPase HSP60 Neighboring gene sphinganine kinase LCB5

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis for glucose-6-phosphate activation of glycogen synthase. Baskaran S, et al. Proc Natl Acad Sci U S A, 2010 Oct 12. PMID 20876143, Free PMC Article
  2. Purification, characterization and partial amino acid sequence of glycogen synthase from Saccharomyces cerevisiae. Carabaza A, et al. Biochem J, 1990 Jun 1. PMID 2114092, Free PMC Article
  3. A potential mechanism of energy-metabolism oscillation in an aerobic chemostat culture of the yeast Saccharomyces cerevisiae. Xu Z, et al. FEBS J, 2006 Apr. PMID 16623706
  4. Glycogen synthase sensitivity to glucose-6-P is important for controlling glycogen accumulation in Saccharomyces cerevisiae. Pederson BA, et al. J Biol Chem, 2004 Apr 2. PMID 14742447
  5. Structural basis for 2'-phosphate incorporation into glycogen by glycogen synthase. Chikwana VM, et al. Proc Natl Acad Sci U S A, 2013 Dec 24. PMID 24324135, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycogen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in glycogen granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
Preferred Names
glycogen (starch) synthase GSY2
NP_013359.1
  • Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    660716..662833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182145.1 → NP_013359.1  glycogen (starch) synthase GSY2

    See identical proteins and their annotated locations for NP_013359.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYQ5, P27472
    UniProtKB/TrEMBL
    A7A1D9, B3RHE1, C7GQY1, G2WJ83, N1NZH7
    Conserved Domains (1) summary
    cd03793
    Location:7 → 616
    GT3_GSY2-like; glycogen synthase GSY2 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27472.3

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