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CQD2 Cqd2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850955, updated on 16-Mar-2025

Summary

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Official Symbol
CQD2
Official Full Name
Cqd2p
Primary source
SGD:S000004243
Locus tag
YLR253W
See related
AllianceGenome:SGD:S000004243; FungiDB:YLR253W; VEuPathDB:YLR253W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MCP2; MRX13
Summary
Involved in lipid homeostasis and mitochondrion organization. Located in mitochondrial inner membrane. Orthologous to several human genes including ADCK1 (aarF domain containing kinase 1). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See CQD2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (642627..644336)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene nucleobindin SSP120 Neighboring gene ethanol metabolism protein Neighboring gene Ndl1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae. Kemmerer ZA, et al. Nat Commun, 2021 Aug 6. PMID 34362905, Free PMC Article
  2. Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes. Tu BP, et al. Science, 2005 Nov 18. PMID 16254148
  3. Mcp1 and Mcp2, two novel proteins involved in mitochondrial lipid homeostasis. Tan T, et al. J Cell Sci, 2013 Aug 15. PMID 23781023
  4. The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria. Khosravi S, et al. J Cell Sci, 2023 May 15. PMID 37073556, Free PMC Article
  5. Contribution of ERMES subunits to mature peroxisome abundance. Esposito M, et al. PLoS One, 2019. PMID 30908556, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cqd2p
NP_013354.1
  • Mitochondrial protein involved in lipid homeostasis; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; associates with mitochondrial ribosome; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of ERMES complex; transcription is periodic during metabolic cycle; homologous to human aarF domain containing kinase, ADCK1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    642627..644336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182140.1 → NP_013354.1  TPA: Cqd2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013354.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYQ0, Q06567
    UniProtKB/TrEMBL
    A7A1D5, B3RHD7, B5VNG7, C7GQY4, C8ZDL6, G2WJ78, N1P1F2
    Conserved Domains (1) summary
    COG0661
    Location:47 → 569
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06567.1

Gene LinkOut

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