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ARV1 sterol homeostasis protein ARV1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850943, updated on 9-Dec-2024

Summary

Official Symbol
ARV1
Official Full Name
sterol homeostasis protein ARV1
Primary source
SGD:S000004232
Locus tag
YLR242C
See related
AllianceGenome:SGD:S000004232; FungiDB:YLR242C; VEuPathDB:YLR242C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable zinc ion binding activity. Involved in several processes, including intracellular lipid transport; membrane lipid biosynthetic process; and regulation of plasma membrane sterol distribution. Located in Golgi apparatus and cortical endoplasmic reticulum. Used to study developmental and epileptic encephalopathy 38 and lipid storage disease. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See ARV1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (622918..623883, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 3-kinase VPS34 Neighboring gene Csc1p Neighboring gene putative signal sequence-binding GTPase GPN3 Neighboring gene methionine aminopeptidase MAP1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in ER to Golgi ceramide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular sterol transport IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular sterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of plasma membrane sterol distribution IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of plasma membrane sterol distribution IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol import IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sterol import IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cortical endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sterol homeostasis protein ARV1
NP_013343.1
  • Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    622918..623883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182129.1NP_013343.1  TPA: sterol homeostasis protein ARV1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013343.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYP0, Q06541, Q2VQX3
    UniProtKB/TrEMBL
    A7A1C5, B3RHC7, B5VNF9, C7GQZ4, C8ZDK5, G2WJ68
    Conserved Domains (1) summary
    cl21705
    Location:1287
    Arv1; Arv1-like family