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FAR10 Far10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850939, updated on 12-Aug-2026
Official Symbol
FAR10
Official Full Name
Far10p
Primary source
SGD:S000004228
Locus tag
YLR238W
See related
AllianceGenome:SGD:S000004228; FungiDB:YLR238W; VEuPathDB:YLR238W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in re-entry into mitotic cell cycle after pheromone arrest. Located in endoplasmic reticulum. Orthologous to human SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See FAR10 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (614755..616191)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene thiamine transporter THI7 Neighboring gene lipoyl(octanoyl) transferase LIP2 Neighboring gene phosphatidylinositol 3-kinase VPS34

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast. Lai F, et al. FEMS Yeast Res, 2011 Feb. PMID 20977626
  2. Tiered assembly of the yeast Far3-7-8-9-10-11 complex at the endoplasmic reticulum. Pracheil T, et al. J Biol Chem, 2013 Jun 7. PMID 23625923, Free PMC Article
  3. The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion. Niphadkar S, et al. PLoS Genet, 2024 Mar. PMID 38452140, Free PMC Article
  4. Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy. Innokentev A, et al. Elife, 2020 Dec 15. PMID 33317697, Free PMC Article
  5. Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae. Kemp HA, et al. Mol Cell Biol, 2003 Mar. PMID 12588993, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to pheromone NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in re-entry into mitotic cell cycle after pheromone arrest IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of TORC2 signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of autophagy NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIP/STRIPAK complex NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
Far10p
NP_013339.1
  • Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    614755..616191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182125.1 → NP_013339.1  Far10p

    See identical proteins and their annotated locations for NP_013339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYN6, Q06001
    UniProtKB/TrEMBL
    B3RHC3
    Conserved Domains (2) summary
    COG1716
    Location:49 → 229
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cl27104
    Location:316 → 432
    Mak16; Mak16 protein C-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06001.1

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