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NDST2 N-deacetylase and N-sulfotransferase 2 [ Homo sapiens (human) ]

Gene ID: 8509, updated on 24-Nov-2020

Summary

Official Symbol
NDST2provided by HGNC
Official Full Name
N-deacetylase and N-sulfotransferase 2provided by HGNC
Primary source
HGNC:HGNC:7681
See related
Ensembl:ENSG00000166507 Ensembl:ENSG00000272916 MIM:603268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NST2; HSST2; N-HSST 2
Summary
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in spleen (RPKM 13.3), bone marrow (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See NDST2 in Genome Data Viewer
Location:
10q22.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (73801916..73811820, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75561669..75571589, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene chromosome 10 putative open reading frame 55 Neighboring gene plasminogen activator, urokinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129697, MGC129705

Gene Ontology Provided by GOA

Function Evidence Code Pubs
[heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
glycosaminoglycan biosynthetic process TAS
Traceable Author Statement
more info
 
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
Names
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
N-heparan sulfate sulfotransferase 2
glucosaminyl N-deacetylase/N-sulfotransferase 2
NP_001317036.1
NP_003626.1
XP_005270313.1
XP_011538612.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046905.1 RefSeqGene

    Range
    5234..14916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330107.2NP_001317036.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC022400, AL045074, AU125430, BC035711, CN266932, DN999958
    Consensus CDS
    CCDS81476.1
    UniProtKB/Swiss-Prot
    P52849
    UniProtKB/TrEMBL
    S4R438
    Related
    ENSP00000475031.1, ENST00000603027.5
    Conserved Domains (2) summary
    pfam00685
    Location:603797
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:25514
    HSNSD; heparan sulfate-N-deacetylase
  2. NM_003635.4NP_003626.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_003626.1

    Status: REVIEWED

    Source sequence(s)
    AK303648, BC035711
    Consensus CDS
    CCDS7335.1
    UniProtKB/Swiss-Prot
    P52849
    UniProtKB/TrEMBL
    B4E139
    Related
    ENSP00000310657.6, ENST00000309979.11
    Conserved Domains (2) summary
    pfam00685
    Location:603852
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:25514
    HSNSD; heparan sulfate-N-deacetylase

RNA

  1. NR_160743.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400
  2. NR_160744.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC022400
  3. NR_160745.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is represented as non-coding because it lacks the coding region found in variant 1.
    Source sequence(s)
    AC022400, AK303648, BC018681
    Related
    ENST00000398701.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    73801916..73811820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540310.3XP_011538612.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_011538612.1

    UniProtKB/Swiss-Prot
    P52849
    Conserved Domains (2) summary
    pfam00685
    Location:603852
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:25514
    HSNSD; heparan sulfate-N-deacetylase
  2. XM_005270256.4XP_005270313.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X2

    See identical proteins and their annotated locations for XP_005270313.1

    UniProtKB/TrEMBL
    B4DU70
    Conserved Domains (2) summary
    pfam00685
    Location:229478
    Sulfotransfer_1; Sulfotransferase domain
    pfam12062
    Location:1140
    HSNSD; heparan sulfate-N-deacetylase
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