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NOP56 snoRNP complex protein NOP56 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850894, updated on 18-Jan-2023

Summary

Gene symbol
NOP56
Gene description
snoRNP complex protein NOP56
Primary source
SGD:S000004187
Locus tag
YLR197W
See related
AllianceGenome:SGD:S000004187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SIK1
Summary
Enables mRNA binding activity. Involved in rRNA processing. Located in nucleolus. Part of box C/D RNP complex and small-subunit processome. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 36. Orthologous to human NOP56 (NOP56 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See NOP56 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (546097..547611)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene glycylpeptide N-tetradecanoyltransferase NMT1 Neighboring gene rRNA-processing protein PWP1 Neighboring gene Pba1p Neighboring gene tubulin-binding prefolding complex subunit YKE2

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the NOP56 gene: The NOP56 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables snoRNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in rRNA modification TAS
Traceable Author Statement
more info
PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
part_of box C/D RNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of box C/D RNP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of box C/D RNP complex IEA
Inferred from Electronic Annotation
more info
 
part_of box C/D RNP complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleolus HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
PubMed 
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
snoRNP complex protein NOP56
NP_013298.1
  • Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    546097..547611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182084.1NP_013298.1  TPA: snoRNP complex protein NOP56 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013298.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYK0, Q12460
    UniProtKB/TrEMBL
    A0A0L8VKV8, A0A8H4BZG5, A7A187, B5VNB7, C7GIS9, H0GKD0, N1P1B4
    Conserved Domains (2) summary
    COG1498
    Location:48447
    SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
    pfam08156
    Location:672
    NOP5NT; NOP5NT (NUC127) domain