PWP1 rRNA-processing protein PWP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PWP1
Official Full Name: rRNA-processing protein PWP1
Primary source: SGD:S000004186
Locus tag: YLR196W
See related: AllianceGenome:SGD:S000004186; FungiDB:YLR196W; VEuPathDB:YLR196W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in rRNA processing. Located in cytoplasm and nucleolus. Orthologous to human PWP1 (PWP1 homolog, endonuclein). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Misfolded pre-rRNAs are stable in the absence of Nop12 but rapidly turned over when Pwp1 is not present.
Title: Ribosome assembly factors Pwp1 and Nop12 are important for folding of 5.8S rRNA during ribosome biogenesis in Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables histone H4K20me3 reader activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_013297.1

Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily

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The following sections contain reference sequences that belong to a specific genome build. Explain