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SWI6 transcriptional regulator SWI6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850879, updated on 18-Sep-2024

Summary

Official Symbol
SWI6
Official Full Name
transcriptional regulator SWI6
Primary source
SGD:S000004172
Locus tag
YLR182W
See related
AllianceGenome:SGD:S000004172; FungiDB:YLR182W; VEuPathDB:YLR182W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PSL8; SDS11
Summary
Enables transcription coactivator activity. Involved in positive regulation of reciprocal meiotic recombination; positive regulation of transcription from RNA polymerase II promoter in response to heat stress; and positive regulation of transcription involved in G1/S transition of mitotic cell cycle. Located in cytoplasm and nucleus. Part of MBF transcription complex and SBF transcription complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SWI6 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (517940..520351)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene methionine adenosyltransferase SAM1 Neighboring gene Vta1p Neighboring gene Tos4p Neighboring gene ribosomal 60S subunit protein L37A

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of MBF transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MBF transcription complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of SBF transcription complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SBF transcription complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SBF transcription complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of SBF transcription complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcriptional regulator SWI6
NP_013283.1
  • Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    517940..520351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182069.1NP_013283.1  TPA: transcriptional regulator SWI6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013283.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYI6, P09959
    UniProtKB/TrEMBL
    G2WJ15, N1NZS2
    Conserved Domains (5) summary
    PHA03095
    Location:308509
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:537773
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:317348
    ANK; ANK repeat [structural motif]
    pfam00023
    Location:469501
    Ank; Ankyrin repeat
    pfam18530
    Location:4106
    Swi6_N; Swi6 N-terminal domain