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SPE4 spermine synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850838, updated on 3-May-2025
Official Symbol
SPE4
Official Full Name
spermine synthase
Primary source
SGD:S000004136
Locus tag
YLR146C
See related
AllianceGenome:SGD:S000004136; FungiDB:YLR146C; VEuPathDB:YLR146C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables spermine synthase activity. Involved in pantothenate biosynthetic process and spermine biosynthetic process. Located in cytoplasm. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, May 2025]
Orthologs
all
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See SPE4 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (432823..433725, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene endo-1,3(4)-beta-glucanase Neighboring gene Rmp1p Neighboring gene uncharacterized protein Neighboring gene mRNA splicing protein SMD3

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Spermine is not essential for growth of Saccharomyces cerevisiae: identification of the SPE4 gene (spermine synthase) and characterization of a spe4 deletion mutant. Hamasaki-Katagiri N, et al. Gene, 1998 Apr 14. PMID 9573363
  2. Regulatory mutations affecting ornithine decarboxylase activity in Saccharomyces cerevisiae. Cohn MS, et al. J Bacteriol, 1980 Jun. PMID 6991493, Free PMC Article
  3. Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism. Olin-Sandoval V, et al. Nature, 2019 Aug. PMID 31367038, Free PMC Article
  4. Disruption of six Saccharomyces cerevisiae ORFs on chromosome XII results in three lethal disruptants. Alloush HM, et al. Yeast, 2002 Jan 15. PMID 11754485
  5. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. White WH, et al. J Biol Chem, 2001 Apr 6. PMID 11154694

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables spermidine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables spermine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pantothenate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within polyamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in spermine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
spermine synthase
NP_013247.1
  • Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    432823..433725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182033.1 → NP_013247.1  TPA: spermine synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013247.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYE0, Q12455, Q2VQW3
    UniProtKB/TrEMBL
    A7A144, B3LTA6, C7GMJ7, C8ZDB5, N1NZQ6
    Conserved Domains (1) summary
    TIGR00417
    Location:14 → 293
    speE; spermidine synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12455.1

Gene LinkOut

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