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SLS1 Sls1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850830, updated on 7-Jun-2026
Official Symbol
SLS1
Official Full Name
Sls1p
Primary source
SGD:S000004129
Locus tag
YLR139C
See related
AllianceGenome:SGD:S000004129; FungiDB:YLR139C; VEuPathDB:YLR139C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in aerobic respiration and mitochondrial translation. Located in mitochondrial inner membrane and mitochondrial nucleoid. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See SLS1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (421542..423473, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene Nha1p Neighboring gene Rrn5p Neighboring gene proline dehydrogenase

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. SLS1, a new Saccharomyces cerevisiae gene involved in mitochondrial metabolism, isolated as a syntheticlethal in association with an SSM4 deletion. Rouillard JM, et al. Mol Gen Genet, 1996 Oct 28. PMID 8917313
  2. Sls1p is a membrane-bound regulator of transcription-coupled processes involved in Saccharomyces cerevisiae mitochondrial gene expression. Bryan AC, et al. Genetics, 2002 Jan. PMID 11805046, Free PMC Article
  3. Multiple interactions involving the amino-terminal domain of yeast mtRNA polymerase determine the efficiency of mitochondrial protein synthesis. Rodeheffer MS, et al. J Biol Chem, 2003 May 16. PMID 12637560, Free PMC Article
  4. Identification of proteins associated with the yeast mitochondrial RNA polymerase by tandem affinity purification. Markov DA, et al. Yeast, 2009 Aug. PMID 19536766, Free PMC Article
  5. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Chen XJ, et al. Science, 2005 Feb 4. PMID 15692048

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
Preferred Names
Sls1p
NP_013240.1
  • Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    421542..423473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182026.1 → NP_013240.1  Sls1p

    See identical proteins and their annotated locations for NP_013240.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYD4, P42900, Q6B228
    UniProtKB/TrEMBL
    A7A138, B3LTA0, B5VN69, C7GMJ1, C8ZDA8, N1NYA1
    Conserved Domains (1) summary
    pfam14611
    Location:146 → 343
    SLS; Mitochondrial inner-membrane-bound regulator
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42900.1

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