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SRN2 ESCRT-I subunit protein SRN2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850810, updated on 30-Jul-2025
Official Symbol
SRN2
Official Full Name
ESCRT-I subunit protein SRN2
Primary source
SGD:S000004109
Locus tag
YLR119W
See related
AllianceGenome:SGD:S000004109; FungiDB:YLR119W; VEuPathDB:YLR119W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SRN10; VPL16; VPS37
Summary
Involved in ATP export; protein targeting to membrane; and protein targeting to vacuole. Located in endosome. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See SRN2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (385534..386175)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Clf1p Neighboring gene palmitoyl-(protein) hydrolase Neighboring gene aspartyl protease Neighboring gene aspartyl protease

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Isolation of an extragenic suppressor of the rna1-1 mutation in Saccharomyces cerevisiae. Hong SJ, et al. Mol Gen Genet, 1998 Sep. PMID 9790597
  2. Efficient cargo sorting by ESCRT-I and the subsequent release of ESCRT-I from multivesicular bodies requires the subunit Mvb12. Curtiss M, et al. Mol Biol Cell, 2007 Feb. PMID 17135292, Free PMC Article
  3. ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Teo H, et al. Cell, 2006 Apr 7. PMID 16615893
  4. Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. Teo H, et al. J Biol Chem, 2004 Jul 2. PMID 15044434
  5. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Katzmann DJ, et al. Cell, 2001 Jul 27. PMID 11511343

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP export IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome transport via multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of protein localization to vacuole IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
part_of ESCRT I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
Preferred Names
ESCRT-I subunit protein SRN2
NP_013220.1
  • Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    385534..386175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182006.1 → NP_013220.1  TPA: ESCRT-I subunit protein SRN2

    See identical proteins and their annotated locations for NP_013220.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VYB7, Q02806, Q99176
    UniProtKB/TrEMBL
    A7A121, N1P168
    Conserved Domains (1) summary
    pfam07200
    Location:57 → 202
    Mod_r; Modifier of rudimentary (Mod(r)) protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99176.1

Gene LinkOut

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