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REA1 AAA family ATPase midasin [ Saccharomyces cerevisiae S288C ]

Gene ID: 850796, updated on 8-Sep-2022

Summary

Gene symbol
REA1
Gene description
AAA family ATPase midasin
Primary source
SGD:S000004096
Locus tag
YLR106C
See related
AllianceGenome:SGD:S000004096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MDN1
Summary
Enables ATP hydrolysis activity. Involved in rRNA processing; regulation of ribosomal subunit export from nucleus; and ribonucleoprotein complex subunit organization. Located in nucleoplasm. Orthologous to human MDN1 (midasin AAA ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See REA1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (349006..363738, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit SEN2 Neighboring gene ncRNA Neighboring gene RNA exonuclease Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the REA1 gene: The REA1 gene is conserved in S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, and N.crassa.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein-RNA complex remodeling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-RNA complex remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ribosomal subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of ribosomal subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ribosomal large subunit assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
AAA family ATPase midasin
NP_013207.1
  • Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex; involved with interaction partners Rsa4p and Ytm1p, in the ATP-dependent remodeling of the pre-60S particle at successive maturation steps during ribosomal biogenesis; involved in the removal of biogenesis factors including GTPase Nog2p prior to nuclear export; contains a hexameric AAA-motor head domain and a long flexible tail with a MIDAS (metal ion-dependent adhesion site) domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    349006..363738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181993.1NP_013207.1  TPA: AAA family ATPase midasin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013207.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q12019, Q7LGX0
    UniProtKB/TrEMBL
    A0A8H4BZH1
    Conserved Domains (1) summary
    COG5271
    Location:894910
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]