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CDC45 DNA replication initiation factor CDC45 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850793, updated on 22-Nov-2020

Summary

Gene symbol
CDC45
Gene description
DNA replication initiation factor CDC45
Primary source
SGD:S000004093
Locus tag
YLR103C
Gene type
protein coding
RNA name
DNA replication initiation factor CDC45
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLD4

Genomic context

See CDC45 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (343989..345941, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene 3-keto-steroid reductase Neighboring gene anaphase promoting complex subunit 9 Neighboring gene Lcl2p Neighboring gene tRNA splicing endonuclease subunit SEN2

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the CDC45 gene: The CDC45 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
DNA replication initiation IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via break-induced replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of chromatin silencing at telomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of chromatin silencing at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
CMG complex IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pre-replicative complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear replication fork IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
replication fork protection complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA replication initiation factor CDC45
NP_013204.1
  • DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    343989..345941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181990.1NP_013204.1  TPA: DNA replication initiation factor CDC45 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q08032
    Conserved Domains (1) summary
    pfam02724
    Location:28647
    CDC45; CDC45-like protein
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