GAA1 GPI-anchor transamidase subunit GAA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GAA1
Official Full Name: GPI-anchor transamidase subunit GAA1
Primary source: SGD:S000004078
Locus tag: YLR088W
See related: AllianceGenome:SGD:S000004078; FungiDB:YLR088W; VEuPathDB:YLR088W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: END2
Summary: Involved in attachment of GPI anchor to protein. Located in endoplasmic reticulum. Part of GPI-anchor transamidase complex. Orthologous to human GPAA1 (glycosylphosphatidylinositol anchor attachment 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase, assemble into a complex.
Title: The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase (GPI-T), assemble into a complex.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in attachment of GPI anchor to protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in attachment of GPI anchor to protein	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GPI-anchor transamidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GPI-anchor transamidase complex	IDA Inferred from Direct Assay more info	PubMed
part_of GPI-anchor transamidase complex	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_013189.1

Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth defects of yeast thermosensitive mutant at restrictive temperature