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FRS1 phenylalanine--tRNA ligase subunit beta [ Saccharomyces cerevisiae S288C ]

Gene ID: 850749, updated on 6-Jul-2026
Official Symbol
FRS1
Official Full Name
phenylalanine--tRNA ligase subunit beta
Primary source
SGD:S000004050
Locus tag
YLR060W
See related
AllianceGenome:SGD:S000004050; FungiDB:YLR060W; VEuPathDB:YLR060W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sequence-specific mRNA binding activity. Contributes to phenylalanine-tRNA ligase activity. Involved in phenylalanyl-tRNA aminoacylation. Located in cytoplasm. Part of phenylalanine-tRNA ligase complex. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See FRS1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (260979..262766)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene glycine hydroxymethyltransferase SHM2 Neighboring gene Rex2p Neighboring gene 60S ribosomal protein eL22 RPL22A Neighboring gene 25S rRNA (uracil2843-N3)-methyltransferase

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Phenylalanyl-tRNA synthetase contains a dispensable RNA-binding domain that contributes to the editing of noncognate aminoacyl-tRNA. Roy H, et al. Biochemistry, 2006 Aug 1. PMID 16866361
  2. Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Mohler K, et al. Nucleic Acids Res, 2017 Apr 20. PMID 28168297, Free PMC Article
  3. Identification of the major tRNA(Phe) binding domain in the tetrameric structure of cytoplasmic phenylalanyl-tRNA synthetase from baker's yeast. Fasiolo F, et al. FEBS Lett, 1989 Jan 2. PMID 2644133
  4. Cation dependence of the transfer reaction catalyzed by phenylalanyl transfer ribonucleic acid synthetase from Bakers' yeast. Robison B, et al. J Biol Chem, 1971 Aug 10. PMID 5562349
  5. Design of a bacterial host for site-specific incorporation of p-bromophenylalanine into recombinant proteins. Kwon I, et al. J Am Chem Soc, 2006 Sep 13. PMID 16953616

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to phenylalanine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phenylalanine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
phenylalanine--tRNA ligase subunit beta
NP_013161.1
  • Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    260979..262766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181947.1 → NP_013161.1  phenylalanine--tRNA ligase subunit beta

    See identical proteins and their annotated locations for NP_013161.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY62, E9P8X0, P15624
    UniProtKB/TrEMBL
    B3LT31
    Conserved Domains (1) summary
    TIGR00471
    Location:1 → 595
    pheT_arch; phenylalanyl-tRNA synthetase, beta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15624.3

Gene LinkOut

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