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ERG3 C-5 sterol desaturase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850745, updated on 9-Jun-2024

Summary

Gene symbol
ERG3
Gene description
C-5 sterol desaturase
Primary source
FungiDB:YLR056W
Locus tag
YLR056W
See related
SGD:S000004046; AllianceGenome:SGD:S000004046; VEuPathDB:YLR056W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PSO6; SYR1
Summary
Enables C-5 sterol desaturase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum lumen. Orthologous to human SC5D (sterol-C5-desaturase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ERG3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (253861..254958)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Osw2p Neighboring gene SAGA complex subunit SPT8 Neighboring gene putative mannosidase MNL2 Neighboring gene glycine hydroxymethyltransferase SHM2

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables C-5 sterol desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables C-5 sterol desaturase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables C-5 sterol desaturase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables delta7-sterol 5(6)-desaturase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
C-5 sterol desaturase
NP_013157.1
  • C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    253861..254958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181943.1NP_013157.1  TPA: C-5 sterol desaturase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013157.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY58, P32353
    UniProtKB/TrEMBL
    A0A8H4BZE0, A7A0W1, C7GQN3, C8ZD28, G2WIP9, N1P0Z8
    Conserved Domains (1) summary
    COG3000
    Location:77350
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]