NRS1 Nrs1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: NRS1
Official Full Name: Nrs1p
Primary source: SGD:S000004043
Locus tag: YLR053C
See related: AllianceGenome:SGD:S000004043; FungiDB:YLR053C; VEuPathDB:YLR053C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables promoter-specific chromatin binding activity and transcription coactivator activity. Involved in cellular response to nitrogen starvation and positive regulation of transcription by RNA polymerase II. Is active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.
Title: The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to nitrogen starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nitrogen starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed

NP_013154.1

Nitrogen-responsive activator of Start; nuclear microprotein with transcriptional activator activity; bypasses Start arrest in a cln3 bck2 double mutant when overexpressed; interacts with subunits of the SBF complex (Swi4p-Swi6p); induced by nitrogen limitation and rapamycin with peak abundance at Start; proposed to promote the G1/S transition by rewiring the G1/S transcriptional machinery under poor nitrogen conditions upstream of the Whi5-inhibited form of SBF and independent of Cln3 and Bck2