PDC1 indolepyruvate decarboxylase 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PDC1
Official Full Name: indolepyruvate decarboxylase 1
Primary source: SGD:S000004034
Locus tag: YLR044C
See related: AllianceGenome:SGD:S000004034; FungiDB:YLR044C; VEuPathDB:YLR044C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables branched-chain-2-oxoacid decarboxylase activity and pyruvate decarboxylase activity. Involved in aromatic amino acid family catabolic process and glycolytic fermentation to ethanol. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See PDC1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (232390..234081, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of pyruvate decarboxylase (pdc1, pdc5) gene knockout on the production of metabolites in two haploid Saccharomyces cerevisiae strains.
Title: Effects of pyruvate decarboxylase (pdc1, pdc5) gene knockout on the production of metabolites in two haploid Saccharomyces cerevisiae strains.
These results suggest that the Pdc1p phosphorylation dependent on SIT4 occurs at residues that change the apparent affinity for thiamine pyrophosphate and pyruvate.
Title: Pyruvate decarboxylase activity is regulated by the Ser/Thr protein phosphatase Sit4p in the yeast Saccharomyces cerevisiae.
mutation of the PDC1 gene improves lactate production in the yeast Saccharomyces cerevisiae
Title: Double mutation of the PDC1 and ADH1 genes improves lactate production in the yeast Saccharomyces cerevisiae expressing the bovine lactate dehydrogenase gene.
Data show that five generations of directed evolution resulted in yeast pyruvate decarboxylase 1 (Pdc1) variants with improved activity for 1 mM pyruvate at pH 7.5 in the presence of phosphate.
Title: Directed evolution of yeast pyruvate decarboxylase 1 for attenuated regulation and increased stability.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4-hydroxyphenylpyruvate decarboxylase activity	RCA inferred from Reviewed Computational Analysis more info
enables branched-chain-2-oxoacid decarboxylase activity	EXP Inferred from Experiment more info	PubMed
enables branched-chain-2-oxoacid decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-2-oxoacid decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables branched-chain-2-oxoacid decarboxylase activity	RCA inferred from Reviewed Computational Analysis more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables indolepyruvate decarboxylase activity	EXP Inferred from Experiment more info	PubMed
enables indolepyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables indolepyruvate decarboxylase activity	RCA inferred from Reviewed Computational Analysis more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables phenylpyruvate decarboxylase activity	EXP Inferred from Experiment more info	PubMed
enables phenylpyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables phenylpyruvate decarboxylase activity	RCA inferred from Reviewed Computational Analysis more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pyruvate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyruvate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables pyruvate decarboxylase activity	RCA inferred from Reviewed Computational Analysis more info
enables thiamine pyrophosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-isoleucine catabolic process	RCA inferred from Reviewed Computational Analysis more info
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in L-phenylalanine catabolic process	RCA inferred from Reviewed Computational Analysis more info
involved_in L-tryptophan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-tryptophan catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in L-tryptophan catabolic process	RCA inferred from Reviewed Computational Analysis more info
involved_in L-tyrosine catabolic process	RCA inferred from Reviewed Computational Analysis more info
involved_in L-valine catabolic process	RCA inferred from Reviewed Computational Analysis more info
involved_in acetoin biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in ethanol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyruvate fermentation to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in secondary alcohol metabolic process	RCA inferred from Reviewed Computational Analysis more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: indolepyruvate decarboxylase 1

NP_013145.1

EC 4.1.1.43

EC 4.1.1.72

EC 4.1.1.74

Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; protein tyrosine nitration on Tyr157 or Tyr344 inhibits activity and impairs fermentation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

232390..234081 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181931.1 → NP_013145.1 indolepyruvate decarboxylase 1

See identical proteins and their annotated locations for NP_013145.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY46, O00042, P06169, Q07991, Q12682, Q12686, Q12687

UniProtKB/TrEMBL

A7A0U9, B3LT15, G2WIN6

Conserved Domains (1) summary

COG3961
Location:1 → 563

PDC1; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]