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RIC1 Ric1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850728, updated on 13-Apr-2024

Summary

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Gene symbol
RIC1
Gene description
Ric1p
Primary source
SGD:S000004029
Locus tag
YLR039C
See related
AllianceGenome:SGD:S000004029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in intracellular protein transport and retrograde transport, endosome to Golgi. Located in Golgi membrane and cis-Golgi network. Part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Orthologous to human RIC1 (RIC1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (225426..228596, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene seripauperin PAU23 Neighboring gene cytochrome c oxidase subunit VIb Neighboring gene Afb1p Neighboring gene Nfg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RIC1, a novel gene required for ribosome synthesis in Saccharomyces cerevisiae. Mizuta K, et al. Gene, 1997 Mar 18. PMID 9099877
  2. Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors. Suástegui M, et al. Metab Eng, 2017 Jul. PMID 28625755
  3. Characterization of MYR1, a dosage suppressor of YPT6 and RIC1 deficient mutants. Georgiev A, et al. Curr Genet, 2008 Apr. PMID 18327588
  4. Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p. Siniossoglou S, et al. EMBO J, 2000 Sep 15. PMID 10990452, Free PMC Article
  5. Decreased aluminium tolerance in the growth of Saccharomyces cerevisiae with SSO2 gene disruption. Yamamoto T, et al. Biometals, 2018 Apr. PMID 29383568

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ric1p
NP_013140.1
  • Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    225426..228596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181926.1 → NP_013140.1  TPA: Ric1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013140.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY42, P40395
    UniProtKB/TrEMBL
    A0A8H4BX68, B3LT11, C7GU50, C8ZD11
    Conserved Domains (1) summary
    pfam07064
    Location:820 → 1045
    RIC1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40395.1

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