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BRE2 Bre2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850702, updated on 9-Dec-2024

Summary

Official Symbol
BRE2
Official Full Name
Bre2p
Primary source
SGD:S000004005
Locus tag
YLR015W
See related
AllianceGenome:SGD:S000004005; FungiDB:YLR015W; VEuPathDB:YLR015W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CPS60
Summary
Contributes to histone H3K4 methyltransferase activity. Involved in subtelomeric heterochromatin formation and telomere maintenance. Part of Set1C/COMPASS complex. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See BRE2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (175227..176744)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Gat3p Neighboring gene Ppr1p Neighboring gene Pml1p Neighboring gene S-methyl-5-thioadenosine phosphorylase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to histone H3K4 methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
 
part_of Set1C/COMPASS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Bre2p
NP_013115.1
  • Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    175227..176744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181902.1NP_013115.1  TPA: Bre2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VY17, E9PA88, P43132
    UniProtKB/TrEMBL
    B3LSY8, C8ZCY7
    Conserved Domains (1) summary
    cd12872
    Location:101244
    SPRY_Ash2; SPRY domain in Ash2