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PAM18 Pam18p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850694, updated on 18-Apr-2019

Summary

Gene symbol
PAM18
Gene description
Pam18p
Primary source
SGD:S000003998
Locus tag
YLR008C
Gene type
protein coding
RNA name
Pam18p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
TIM14

Genomic context

See PAM18 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (165577..166083, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase SSK1 Neighboring gene Smc5-Smc6 complex subunit NSE1 Neighboring gene ATPase-activating ribosome biosynthesis protein Neighboring gene Ten1p

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PAM complex, Tim23 associated import motor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
PAM complex, Tim23 associated import motor IDA
Inferred from Direct Assay
more info
PubMed 
TIM23 mitochondrial import inner membrane translocase complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Pam18p
NP_013108.1
  • Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    165577..166083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181895.1NP_013108.1  TPA: Pam18p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013108.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07914
    Conserved Domains (2) summary
    cl02542
    Location:103163
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    cl21494
    Location:53148
    Abhydrolase; alpha/beta hydrolases
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