U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NOC3 Noc3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 850688, updated on 8-Sep-2022

Summary

Gene symbol
NOC3
Gene description
Noc3p
Primary source
SGD:S000003992
Locus tag
YLR002C
See related
AllianceGenome:SGD:S000003992
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables chromatin binding activity. Involved in DNA-dependent DNA replication and ribosome biogenesis. Located in nucleolus and nucleoplasm. Part of Noc2p-Noc3p complex and nuclear pre-replicative complex. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NOC3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (154343..156334, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene dynamin-related GTPase DNM1 Neighboring gene uncharacterized protein Neighboring gene Cms1p Neighboring gene Thi73p

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the NOC3 gene: The NOC3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA replication initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Noc2p-Noc3p complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Noc3p
NP_013102.1
  • Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    154343..156334 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181889.1NP_013102.1  TPA: Noc3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07896, Q92280
    UniProtKB/TrEMBL
    A0A8H4BYD1, A7A0Q7, B5VMU3, C7GPF6
    Conserved Domains (1) summary
    COG5117
    Location:1660
    NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]