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FRE6 putative ferric-chelate reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 850675, updated on 10-Feb-2026
Official Symbol
FRE6
Official Full Name
putative ferric-chelate reductase
Primary source
SGD:S000003974
Locus tag
YLL051C
See related
AllianceGenome:SGD:S000003974; FungiDB:YLL051C; VEuPathDB:YLL051C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ferric-chelate reductase activity. Involved in copper ion import. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See FRE6 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (37333..39471, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Aqy2p Neighboring gene cofilin Neighboring gene Ldb18p

Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The metalloreductase Fre6p in Fe-efflux from the yeast vacuole. Singh A, et al. J Biol Chem, 2007 Sep 28. PMID 17681937
  2. Identification of a vacuole-associated metalloreductase and its role in Ctr2-mediated intracellular copper mobilization. Rees EM, et al. J Biol Chem, 2007 Jul 27. PMID 17553781
  3. Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. Martins LJ, et al. J Biol Chem, 1998 Sep 11. PMID 9726978
  4. Exploring metal ion metabolisms to improve xylose fermentation in Saccharomyces cerevisiae. Palermo GCL, et al. Microb Biotechnol, 2021 Sep. PMID 34313008, Free PMC Article
  5. Functional analysis of eight open reading frames on chromosomes XII and XIV of Saccharomyces cerevisiae. Ahmed Khan S, et al. Yeast, 2000 Dec. PMID 11113969

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferric-chelate reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables ferric-chelate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric-chelate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric-chelate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferric-chelate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ferric-chelate reductase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in copper ion import IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transition metal ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative ferric-chelate reductase
NP_013049.1
  • Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; targeted to vacuole via AP-3 pathway

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    37333..39471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181871.1 → NP_013049.1  putative ferric-chelate reductase

    See identical proteins and their annotated locations for NP_013049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXV7, Q12473
    UniProtKB/TrEMBL
    A7A0K9, B3LTC6, B5VMQ1, C7GNE4, N1P6D1
    Conserved Domains (3) summary
    pfam08022
    Location:438 → 544
    FAD_binding_8; FAD-binding domain
    pfam08030
    Location:565 → 692
    NAD_binding_6; Ferric reductase NAD binding domain
    pfam01794
    Location:290 → 402
    Ferric_reduct; Ferric reductase like transmembrane component
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12473.1

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