GTT2 glutathione transferase GTT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GTT2
Official Full Name: glutathione transferase GTT2
Primary source: SGD:S000003983
Locus tag: YLL060C
See related: AllianceGenome:SGD:S000003983; FungiDB:YLL060C; VEuPathDB:YLL060C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutathione transferase activity. Involved in glutathione metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1); GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); and GSTT2B (glutathione S-transferase theta 2B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See GTT2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (21138..21839, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Yeast Gtt2 is a novel atypical type of cytosolic GST.
Title: Structures of yeast glutathione-S-transferase Gtt2 reveal a new catalytic type of GST family.
Glutathione transferases, Gtt1 and Gtt2, seem to be crucial in the response to H2O2 stress.
Title: Involvement of glutathione transferases, Gtt1and Gtt2, with oxidative stress response generated by H2O2 during growth of Saccharomyces cerevisiae.
Gtt1 and Gtt2 play different roles in the mechanism of cadmium detoxification.
Title: The role of glutathione transferases in cadmium stress.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glutathione binding	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	RCA inferred from Reviewed Computational Analysis more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	RCA inferred from Reviewed Computational Analysis more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: glutathione transferase GTT2

NP_013040.1

EC 2.5.1.18

Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

21138..21839 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181880.1 → NP_013040.1 glutathione transferase GTT2

See identical proteins and their annotated locations for NP_013040.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXU9, Q12390

UniProtKB/TrEMBL

A7A0K1, G2WIE1, N1P7B3

Conserved Domains (2) summary

cd03182
Location:106 → 222

GST_C_GTT2_like; C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases

cd03051
Location:19 → 94

GST_N_GTT2_like; GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing ...