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MHT1 S-adenosylmethionine-homocysteine S-methyltransferase MHT1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850664, updated on 8-Feb-2025

Summary

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Official Symbol
MHT1
Official Full Name
S-adenosylmethionine-homocysteine S-methyltransferase MHT1
Primary source
SGD:S000003985
Locus tag
YLL062C
See related
AllianceGenome:SGD:S000003985; FungiDB:YLL062C; VEuPathDB:YLL062C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables S-adenosylmethionine-homocysteine S-methyltransferase activity. Involved in sulfur amino acid metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); autistic disorder; hematologic cancer (multiple); and hyperhomocysteinemia. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Feb 2025]
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Genomic context

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See MHT1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (16639..17613, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene seripauperin PAU18 Neighboring gene acetyltransferase Neighboring gene S-methylmethionine permease MMP1 Neighboring gene glutathione transferase GTT2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells. Thomas D, et al. J Biol Chem, 2000 Dec 29. PMID 11013242
  2. Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2010 Jul 2. PMID 20421295, Free PMC Article
  3. Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2007 Mar 23. PMID 17264075
  4. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. Ranocha P, et al. J Biol Chem, 2000 May 26. PMID 10747987
  5. The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Niepel M, et al. Mol Biol Cell, 2013 Dec. PMID 24152732, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SAM4 and MHT1 have roles in recognition of age-damaged (R,S)-adenosyl-L-methionine
    Title: Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-adenosylmethionine-homocysteine S-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-adenosylmethionine-homocysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables S-methylmethionine-homocysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfur amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
S-adenosylmethionine-homocysteine S-methyltransferase MHT1
NP_013038.1
  • S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    16639..17613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181882.1 → NP_013038.1  TPA: S-adenosylmethionine-homocysteine S-methyltransferase MHT1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013038.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXU7, Q12525
    UniProtKB/TrEMBL
    A7A0J9, B3LTB7, B5VMP4, C7GND5, C8ZCR5, G2WID8
    Conserved Domains (1) summary
    COG2040
    Location:6 → 324
    MHT1; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12525.1

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