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ORC3 origin recognition complex subunit 3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850656, updated on 9-Dec-2024

Summary

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Official Symbol
ORC3
Official Full Name
origin recognition complex subunit 3
Primary source
SGD:S000003927
Locus tag
YLL004W
See related
AllianceGenome:SGD:S000003927; FungiDB:YLL004W; VEuPathDB:YLL004W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA replication origin binding activity and chromatin binding activity. Involved in DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and silent mating-type cassette heterochromatin formation. Part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC3 (origin recognition complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ORC3 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (141073..142923)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ERMES complex subunit MMM1 Neighboring gene Spo75p Neighboring gene Sfi1p Neighboring gene H3 histone acetyltransferase RTT109

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast. Cheng X, et al. J Biol Chem, 2010 Sep 24. PMID 20659900, Free PMC Article
  2. Chromosome integrity in Saccharomyces cerevisiae: the interplay of DNA replication initiation factors, elongation factors, and origins. Huang D, et al. Genes Dev, 2003 Jul 15. PMID 12865298, Free PMC Article
  3. Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Chen S, et al. Genes Dev, 2007 Nov 15. PMID 18006685, Free PMC Article
  4. The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain. Bose ME, et al. Mol Cell Biol, 2004 Jan. PMID 14701749, Free PMC Article
  5. Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae. Knott SR, et al. Cell, 2012 Jan 20. PMID 22265405, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear origin of replication recognition complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of nuclear pre-replicative complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 3
NP_013097.1
  • Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    141073..142923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181824.1 → NP_013097.1  TPA: origin recognition complex subunit 3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013097.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXZ9, P54790
    UniProtKB/TrEMBL
    A7A0Q2, B3LTG2, B5VMT8, C7GPG1, C8ZCW9, N1P0C3
    Conserved Domains (1) summary
    cd20704
    Location:57 → 613
    Orc3; Origin recognition complex subunit 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54790.1

Gene LinkOut

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