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MMM1 ERMES complex subunit MMM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850654, updated on 16-Mar-2025

Summary

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Official Symbol
MMM1
Official Full Name
ERMES complex subunit MMM1
Primary source
SGD:S000003929
Locus tag
YLL006W
See related
AllianceGenome:SGD:S000003929; FungiDB:YLL006W; VEuPathDB:YLL006W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YME6
Summary
Contributes to lipid transfer activity. Involved in aminophospholipid transport; mitochondrion organization; and mitochondrion-endoplasmic reticulum membrane tethering. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Part of ERMES complex. Is active in mitochondria-associated endoplasmic reticulum membrane contact site. [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See MMM1 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (136586..137866)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Lmo1p Neighboring gene uncharacterized protein Neighboring gene Spo75p Neighboring gene origin recognition complex subunit 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria. Burgess SM, et al. J Cell Biol, 1994 Sep. PMID 8089172, Free PMC Article
  2. Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. Kondo-Okamoto N, et al. J Biol Chem, 2003 Dec 5. PMID 12972421
  3. Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability. Hobbs AE, et al. J Cell Biol, 2001 Jan 22. PMID 11266455, Free PMC Article
  4. Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa. Prokisch H, et al. Mol Biol Cell, 2000 Sep. PMID 10982393, Free PMC Article
  5. Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate. Laporte D, et al. Elife, 2018 Oct 9. PMID 30299253, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Therefore, the Mmm1-Mdm12 complex functions as a minimal unit that mediates lipid transfer between membranes.
    Title: Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.
  2. Assembly of mitochondrial beta-barrel proteins represents a major function of the morphology proteins Mdm12/Mmm1.
    Title: The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to lipid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to lipid transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in aminophospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aminophospholipid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial outer membrane translocase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion-endoplasmic reticulum membrane tethering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phospholipid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein insertion into mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in protein insertion into mitochondrial outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ERMES complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ERMES complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ERMES complex IEA
Inferred from Electronic Annotation
more info
  
part_of ERMES complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in peroxisome HDA PubMed 

General protein information

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Preferred Names
ERMES complex subunit MMM1
NP_013095.1
  • ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; localizes to the peroxisome in glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    136586..137866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181826.1 → NP_013095.1  TPA: ERMES complex subunit MMM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013095.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A7A0Q0, B5VMT6, D6VXZ7, P41800
    UniProtKB/TrEMBL
    C7GPG3, C8ZCW7, G2WII9, N1NYY2
    Conserved Domains (1) summary
    pfam10296
    Location:95 → 418
    MMM1; Maintenance of mitochondrial morphology protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41800.2

Gene LinkOut

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