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SSA2 Hsp70 family chaperone SSA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850636, updated on 4-Feb-2024

Summary

Gene symbol
SSA2
Gene description
Hsp70 family chaperone SSA2
Primary source
SGD:S000003947
Locus tag
YLL024C
See related
AllianceGenome:SGD:S000003947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YG102
Summary
Enables ATP binding activity; tRNA binding activity; and unfolded protein binding activity. Involved in several processes, including SRP-dependent cotranslational protein targeting to membrane, translocation; negative regulation of cell aging; and tRNA import into nucleus. Located in several cellular components, including fungal-type cell wall; fungal-type vacuole membrane; and mitochondrion. Part of polysome. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA1B (heat shock protein family A (Hsp70) member 1B) and HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SSA2 in Genome Data Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (95566..97485, complement)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene seripauperin PAU17 Neighboring gene nucleoporin POM33 Neighboring gene Hif1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Hsp70 family chaperone SSA2
NP_013076.1
  • HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation; targeted to vacuole via AP-3 pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    95566..97485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181844.1NP_013076.1  TPA: Hsp70 family chaperone SSA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013076.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXY0, P10592
    UniProtKB/TrEMBL
    A0A8H4BXW7, C8ZCU8
    Conserved Domains (1) summary
    PTZ00009
    Location:4639
    PTZ00009; heat shock 70 kDa protein; Provisional