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ISA1 Fe-binding Fe/S cluster assembly protein ISA1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850632, updated on 9-Jul-2017
Gene symbol
ISA1
Gene description
Fe-binding Fe/S cluster assembly protein ISA1
Primary source
SGD:S000003950
Locus tag
YLL027W
Gene type
protein coding
RNA name
Fe-binding Fe/S cluster assembly protein ISA1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See ISA1 in Map Viewer
Location:
chromosome: XII
Exon count:
1
Sequence:
Chromosome: XII; NC_001144.5 (87403..88155)

Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fra1p Neighboring gene Tpo1p Neighboring gene chaperone ATPase HSP104 Neighboring gene tRNA

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
 
4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
 
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster binding ISA
Inferred from Sequence Alignment
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biotin biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein maturation by iron-sulfur cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Names
Fe-binding Fe/S cluster assembly protein ISA1
NP_013073.1
  • Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001144.5 Reference assembly

    Range
    87403..88155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181847.1NP_013073.1  TPA: Fe-binding Fe/S cluster assembly protein ISA1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013073.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07821
    Conserved Domains (1) summary
    TIGR00049
    Location:148250
    TIGR00049; Iron-sulfur cluster assembly accessory protein
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