IRC7 cysteine-S-conjugate beta-lyase IRC7 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IRC7
Official Full Name: cysteine-S-conjugate beta-lyase IRC7
Primary source: SGD:S000001952
Locus tag: YFR055W
See related: AllianceGenome:SGD:S000001952; FungiDB:YFR055W; VEuPathDB:YFR055W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cysteine-S-conjugate beta-lyase activity. Involved in L-cysteine catabolic process to pyruvate. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See IRC7 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (264204..265226)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Global distribution of IRC7 alleles in Saccharomyces cerevisiae populations: a genomic and phenotypic survey within the wine clade.
Title: Global distribution of IRC7 alleles in Saccharomyces cerevisiae populations: a genomic and phenotypic survey within the wine clade.
allelic variation of IRC7 not only affects the release of thiols but modulates the formation of negative volatile sulfur compounds from the cysteine.
Title: Inactivating Mutations in Irc7p Are Common in Wine Yeasts, Attenuating Carbon-Sulfur β-Lyase Activity and Volatile Sulfur Compound Production.
While IRC7 has been identified as playing a critical role in converting cysteine conjugates to volatile thiols that are important in wine aroma, its biological role in yeast cells is likely to involve regulation of cysteine and redox homeostasis.
Title: The IRC7 gene encodes cysteine desulphydrase activity and confers on yeast the ability to grow on cysteine as a nitrogen source.
IRC7 gene encodes a beta-lyase responsible for production of the varietal thiol 4-mercapto-4-methylpentan-2-one in wine.
Title: The yeast IRC7 gene encodes a β-lyase responsible for production of the varietal thiol 4-mercapto-4-methylpentan-2-one in wine.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-cysteine desulfhydrase activity	IDA Inferred from Direct Assay more info	PubMed
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cysteine-S-conjugate beta-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-S-conjugate beta-lyase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-S-conjugate beta-lyase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-S-conjugate beta-lyase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-cysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-cysteine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-cysteine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sulfur compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfur compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cysteine-S-conjugate beta-lyase IRC7

NP_116714.1

EC 4.4.1.13

Cysteine desulphydrase, enables growth on cysteine as nitrogen source; involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

264204..265226

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180021.1 → NP_116714.1 cysteine-S-conjugate beta-lyase IRC7

See identical proteins and their annotated locations for NP_116714.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTT7, P43623

UniProtKB/TrEMBL

B3LUR6

Conserved Domains (1) summary

COG0626
Location:9 → 340

MetC; Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]