U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BNA6 nicotinate-nucleotide diphosphorylase (carboxylating) [ Saccharomyces cerevisiae S288C ]

Gene ID: 850608, updated on 24-Jul-2025
Official Symbol
BNA6
Official Full Name
nicotinate-nucleotide diphosphorylase (carboxylating)
Primary source
SGD:S000001943
Locus tag
YFR047C
See related
AllianceGenome:SGD:S000001943; FungiDB:YFR047C; VEuPathDB:YFR047C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
QPT1
Summary
Enables nicotinate-nucleotide diphosphorylase (carboxylating) activity. Involved in 'de novo' NAD biosynthetic process from L-tryptophan. Located in cytoplasm and nucleus. Orthologous to human QPRT (quinolinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table
See BNA6 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (244279..245166, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Mrx20p Neighboring gene centromere-binding protein CNN1 Neighboring gene Rmd8p Neighboring gene alpha-ketoglutarate dehydrogenase subunit KGD4

Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Comprehensive X-ray structural studies of the quinolinate phosphoribosyl transferase (BNA6) from Saccharomyces cerevisiae. di Luccio E, et al. Biochemistry, 2008 Apr 1. PMID 18321072
  2. Quantitation of NAD+ biosynthesis from the salvage pathway in Saccharomyces cerevisiae. Sporty J, et al. Yeast, 2009 Jul. PMID 19399913, Free PMC Article
  3. Dihydrolipoyl dehydrogenase as a source of reactive oxygen species inhibited by caloric restriction and involved in Saccharomyces cerevisiae aging. Tahara EB, et al. FASEB J, 2007 Jan. PMID 17110466
  4. Redox responses in yeast to acetate as the carbon source. Minard KI, et al. Arch Biochem Biophys, 2009 Mar 1. PMID 19138656, Free PMC Article
  5. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. Panozzo C, et al. FEBS Lett, 2002 Apr 24. PMID 12062417

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD+ biosynthetic process from L-tryptophan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in NAD+ biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD+ biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
nicotinate-nucleotide diphosphorylase (carboxylating)
NP_602317.3
  • Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    244279..245166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180012.3 → NP_602317.3  TPA: nicotinate-nucleotide diphosphorylase (carboxylating)

    See identical proteins and their annotated locations for NP_602317.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTT0, P43619
    UniProtKB/TrEMBL
    A7A287, B5VI72, C7GYF0, G2WDI8, N1P302
    Conserved Domains (1) summary
    TIGR00078
    Location:17 → 293
    nadC; nicotinate-nucleotide pyrophosphorylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43619.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous