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QCR6 ubiquinol--cytochrome-c reductase subunit 6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850593, updated on 3-Jun-2026
Official Symbol
QCR6
Official Full Name
ubiquinol--cytochrome-c reductase subunit 6
Primary source
SGD:S000001929
Locus tag
YFR033C
See related
AllianceGenome:SGD:S000001929; FungiDB:YFR033C; VEuPathDB:YFR033C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
COR3; UCR6
Summary
Contributes to ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial intermembrane space and nuclear periphery. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to human UQCRH (ubiquinol-cytochrome c reductase hinge protein) and UQCRHL (ubiquinol-cytochrome c reductase hinge protein like). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (224326..224769, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein eL29 RPL29 Neighboring gene Min10p Neighboring gene phosphate-sensing transcription factor PHO4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of novel homologues of three low molecular weight subunits of the mitochondrial bc1 complex. Braun HP. Mol Biol Rep, 1996. PMID 8983020
  2. The DNA sequence of the nuclear gene coding for the 17-kd subunit VI of the yeast ubiquinol-cytochrome c reductase: a protein with an extremely high content of acidic amino acids. Van Loon AP, et al. EMBO J, 1984 May. PMID 6329732, Free PMC Article
  3. Acidic regions of cytochrome c1 are essential for ubiquinol-cytochrome c reductase activity in yeast cells lacking the acidic QCR6 protein. Nakai M, et al. J Biochem, 1993 Dec. PMID 8138552
  4. The cleaved presequence is not required for import of subunit 6 of the cytochrome bc1 complex into yeast mitochondria or assembly into the complex. DeLabre ML, et al. FEBS Lett, 1999 Apr 23. PMID 10338132
  5. Deletion of QCR6, the gene encoding subunit six of the mitochondrial cytochrome bc1 complex, blocks maturation of cytochrome c1, and causes temperature-sensitive petite growth in Saccharomyces cerevisiae. Yang M, et al. J Biol Chem, 1994 Jan 14. PMID 8288589

See all (108) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to quinol-cytochrome-c reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex III IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex III IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
ubiquinol--cytochrome-c reductase subunit 6
NP_116691.3
  • Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    224326..224769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179998.3 → NP_116691.3  ubiquinol--cytochrome-c reductase subunit 6

    See identical proteins and their annotated locations for NP_116691.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTR6, P00127
    UniProtKB/TrEMBL
    A7A273, B3LUP4, C8Z7X0, G2WDH4, N1P520
    Conserved Domains (1) summary
    pfam02320
    Location:76 → 147
    UCR_hinge; Ubiquinol-cytochrome C reductase hinge protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00127.2

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