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CDC14 phosphoprotein phosphatase CDC14 [ Saccharomyces cerevisiae S288C ]

Gene ID: 850585, updated on 15-Feb-2026
Official Symbol
CDC14
Official Full Name
phosphoprotein phosphatase CDC14
Primary source
SGD:S000001924
Locus tag
YFR028C
See related
AllianceGenome:SGD:S000001924; FungiDB:YFR028C; VEuPathDB:YFR028C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
OAF3
Summary
Enables protein serine/threonine phosphatase activity. Involved in several processes, including meiotic spindle disassembly; positive regulation of organelle organization; and rDNA chromatin condensation. Located in several cellular components, including cellular bud neck; new mitotic spindle pole body; and nucleolus. Part of RENT complex. Used to study autosomal recessive nonsyndromic deafness 32; colorectal carcinoma; and vascular disease. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Orthologous to human CDC14A (cell division cycle 14A); CDC14B (cell division cycle 14B); and CDC14C (cell division cycle 14C). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See CDC14 in Genome Data Viewer
Location:
chromosome: VI
Exon count:
1
Sequence:
Chromosome: VI; NC_001138.5 (208413..210068, complement)

Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Uli1p Neighboring gene Eco1p Neighboring gene tRNA-Tyr Neighboring gene Ptr3p

Genomic Sequence:
NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cdc14 Localization as a Marker for Mitotic Exit: In Vivo Quantitative Analysis of Cdc14 Release. Neurohr G, et al. Methods Mol Biol, 2017. PMID 27826856
  2. Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network. Torres-Rosell J, et al. Cell Cycle, 2004 Apr. PMID 15004526
  3. Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14. Wang WQ, et al. J Biol Chem, 2004 Jul 16. PMID 15128740
  4. The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression. Taylor GS, et al. J Biol Chem, 1997 Sep 19. PMID 9295359
  5. Re-examining the role of Cdc14 phosphatase in reversal of Cdk phosphorylation during mitotic exit. Powers BL, et al. J Cell Sci, 2017 Aug 15. PMID 28663385

See all (333) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Saccharomyces cerevisiae deficient in the early anaphase release of Cdc14 can traverse anaphase I without ribosomal DNA disjunction and successfully complete meiosis.
    Title: Saccharomyces cerevisiae deficient in the early anaphase release of Cdc14 can traverse anaphase I without ribosomal DNA disjunction and successfully complete meiosis.
  2. Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
    Title: Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
  3. Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast.
    Title: Interphase chromosome condensation in nutrient-starved conditions requires Cdc14 and Hmo1, but not condensin, in yeast.
  4. Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions.
    Title: Cdc14 spatiotemporally dephosphorylates Atg13 to activate autophagy during meiotic divisions.
  5. Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
    Title: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
  6. Cross-compartment signal propagation in the mitotic exit network.
    Title: Cross-compartment signal propagation in the mitotic exit network.
  7. Cdc14 protein phosphatase and topoisomerase II mediate rDNA dynamics and nucleophagic degradation of nucleolar proteins after TORC1 inactivation.
    Title: Cdc14 protein phosphatase and topoisomerase II mediate rDNA dynamics and nucleophagic degradation of nucleolar proteins after TORC1 inactivation.
  8. The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis.
    Title: The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis.
  9. Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
    Title: Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
  10. Cdc14 plays very specific, and often different, roles in counteracting Cdk phosphorylation in all species.
    Title: Re-examining the role of Cdc14 phosphatase in reversal of Cdk phosphorylation during mitotic exit.
Submit: New GeneRIF Correction See all GeneRIFs (55)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic nuclear division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in meiotic spindle disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA chromatin condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rDNA heterochromatin formation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of cytokinetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of exit from mitosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of exit from mitosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RENT complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in new mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle pole body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphoprotein phosphatase CDC14
NP_116684.3
  • Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001138.5 Reference assembly

    Range
    208413..210068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179993.3 → NP_116684.3  phosphoprotein phosphatase CDC14

    See identical proteins and their annotated locations for NP_116684.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VTQ8, Q00684, Q05180, Q05673
    UniProtKB/TrEMBL
    A7A265, C7GYD2, C8Z7W3, G2WDG6, N1P4Q7
    Conserved Domains (3) summary
    PRK08581
    Location:403 → 513
    PRK08581; amidase domain-containing protein
    cd14499
    Location:161 → 340
    CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
    pfam14671
    Location:14 → 151
    DSPn; Dual specificity protein phosphatase, N-terminal half
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00684.2

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